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Shauna Marvin
Graduate Student
B.A., Interdisciplinary Sciences: Biology-Chemistry,
Lawrence University
M.P.H., University of Kansas School of Medicine-Wichita
"Immune Evasion During Adenovirus Infection"
Adenovirus is recognized by pattern recognition receptors during cell entry which trigger innate immune responses to inhibit viral replication, destroy invading virions and present viral antigens for development of adaptive immunity . My project focuses on mechanisms used by adenovirus to evade recognition and destruction by these innate immune processes during cell entry. By using genetic and cell biological approaches, I am identifying cellular factors which inhibit adenovirus replication as well as determinants in the viral capsid which facilitate adenoviral evasion of these cell factors
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Kathleen McGuire
Graduate Student
B.S, Biology, The College of William and Mary
"The Role of Reactive Oxygen Species in the Innate Immune Response to Adenovirus Infection"
Reactive Oxygen Species (ROS) play a role in the innate immune response to pathogens in several ways. Originally thought to be primarily produced in response to extracellular pathogens such as bacteria, ROS also contribute to the immune response to intracellular pathogens such as viruses. Our preliminary data suggests that ROS are produced in response to adenovirus infection. Further, our data indicates that ROS are required for the pro-inflammatory response to adenovirus. I am interested in elucidating the mechanism of ROS production in response to adenovirus infection, and further, how ROS contributes to the pro-inflammatory response induced by adenovirus. Since adenovirus is a candidate for both vaccines and gene therapy vectors, it is necessary to better understand the pro-inflammatory response to adenovirus infection.
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